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Reverse signalling of membrane-integrated tumour necrosis factor differentially regulates alloresponses of CD4+ and CD8+ T cells against human microvascular endothelial cells

Vudattu, Nalini K ; Holler, Ernst ; Ewing, Patricia ; Schulz, Ute ; Haffner, Silvia ; Burger, Verena ; Kirchner, Silvia ; Andreesen, Reinhard ; Eissner, Günther



Abstract

Reverse signalling of membrane-integrated ligands is a common phenomenon in the tumour necrosis factor (TNF) family and contributes to the pleiotropy of this pro-inflammatory cytokine and to the plasticity of the immune system in general. Transmembrane TNF (mTNF) itself can induce resistance to bacterial endotoxin in monocytes and can stimulate the immune activity of mitogen-activated, as well as ...

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