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Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR

Gebhard, Claudia, Schwarzfischer, Lucia, Pham, Thu Hang, Andreesen, Reinhard, Mackensen, Andreas and Rehli, Michael (2006) Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR. Nucleic acids research 34 (11), e82.

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Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes. We have developed a novel technique for detecting CpG-methylated DNA termed methyl-binding (MB)-PCR. This technique utilizes a recombinant protein with high affinity for CpG-methylated DNA that is coated onto the walls of a PCR vessel and selectively ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
10339513PubMed ID
Acute DiseaseMESH
Cell Line, TumorMESH
Cells, CulturedMESH
CpG IslandsMESH
DNA MethylationMESH
DNA, Neoplasm/chemistryMESH
DNA-Binding ProteinsMESH
Genes, Tumor SuppressorMESH
Interferon Regulatory Factors/geneticsMESH
Leukemia, Myeloid/geneticsMESH
Polymerase Chain Reaction/methodsMESH
Promoter Regions, GeneticMESH
Time FactorsMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14480
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