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Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells.

Fischer, Karin ; Voelkl, Simon ; Berger, Jana ; Andreesen, Reinhard ; Pomorski, Thomas ; Mackensen, Andreas


In eukaryotic cells the phospholipid phosphatidylserine (PS) is restricted to the inner plasma-membrane leaflet. This lipid asymmetry, which is maintained by the concerted action of phospholipid transport proteins, is mainly lost during apoptosis. Here, we demonstrate that primary human CD8+ cytotoxic T lymphocytes (CTLs) expose PS on T-cell receptor (TCR)-mediated antigen (Ag) recognition. In ...


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