Go to content
UR Home

Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells.

Fischer, Karin ; Voelkl, Simon ; Berger, Jana ; Andreesen, Reinhard ; Pomorski, Thomas ; Mackensen, Andreas



Abstract

In eukaryotic cells the phospholipid phosphatidylserine (PS) is restricted to the inner plasma-membrane leaflet. This lipid asymmetry, which is maintained by the concerted action of phospholipid transport proteins, is mainly lost during apoptosis. Here, we demonstrate that primary human CD8+ cytotoxic T lymphocytes (CTLs) expose PS on T-cell receptor (TCR)-mediated antigen (Ag) recognition. In ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons