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Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia

Gebhard, Claudia ; Schwarzfischer, Lucia ; Pham, Thu-Hang ; Schilling, Elmar ; Klug, Maja ; Andreesen, Reinhard ; Rehli, Michael


The methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes. Because aberrant hypermethylation may be used as a marker for disease, a sensitive method for the global detection of DNA methylation events is of particular importance. We describe a novel and robust technique, called methyl-CpG ...


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