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Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia

Gebhard, Claudia ; Schwarzfischer, Lucia ; Pham, Thu-Hang ; Schilling, Elmar ; Klug, Maja ; Andreesen, Reinhard ; Rehli, Michael



Abstract

The methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes. Because aberrant hypermethylation may be used as a marker for disease, a sensitive method for the global detection of DNA methylation events is of particular importance. We describe a novel and robust technique, called methyl-CpG ...

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