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Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite

Gottfried, Eva ; Rehli, Michael ; Hahn, Joachim ; Holler, Ernst ; Andreesen, Reinhard ; Kreutz, Marina



Abstract

CYP27A1 catalyses hydroxylations in the biosynthesis of bile acids and the bioactivation of vitamin D3. We investigated the expression of CYP27A1 in human monocytes, monocyte-derived macrophages, and dendritic cells on mRNA and protein levels as well as its enzymatic activity in comparison with the expression of CYP27B1 and CYP24A1. Macrophages showed a strong expression of CYP27A1, whereas ...

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