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CD8+ T cells reactive to survivin antigen in patients with multiple myeloma

Grube, Matthias ; Moritz, Stephanie ; Obermann, Ellen C. ; Rezvani, Katayoun ; Mackensen, Andreas ; Andreesen, Reinhard ; Holler, Ernst


PURPOSE: Survivin is a member of the inhibitors of apoptosis family and is overexpressed in different types of malignancies. Cytotoxic T cells recognizing survivin epitopes can be elicited in vitro and by vaccination in patients with leukemia, breast cancer, and melanoma. We did this study to investigate whether survivin-specific CD8+ T cells occur in patients with multiple myeloma. EXPERIMENTAL ...


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