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CD8+ T cells reactive to survivin antigen in patients with multiple myeloma

Grube, Matthias, Moritz, Stephanie, Obermann, Ellen C., Rezvani, Katayoun, Mackensen, Andreas, Andreesen, Reinhard and Holler, Ernst (2007) CD8+ T cells reactive to survivin antigen in patients with multiple myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research 13 (3), pp. 1053-60.

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Abstract

PURPOSE: Survivin is a member of the inhibitors of apoptosis family and is overexpressed in different types of malignancies. Cytotoxic T cells recognizing survivin epitopes can be elicited in vitro and by vaccination in patients with leukemia, breast cancer, and melanoma. We did this study to investigate whether survivin-specific CD8+ T cells occur in patients with multiple myeloma. EXPERIMENTAL ...

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Item type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
17289902PubMed ID
10.1158/1078-0432.CCR-06-1722DOI
Classification:
NotationType
AgedMESH
Antigens, CD45/biosynthesisMESH
ApoptosisMESH
CD8-Positive T-Lymphocytes/metabolismMESH
Cell Line, TumorMESH
EpitopesMESH
FemaleMESH
Gene Expression Regulation, NeoplasticMESH
HumansMESH
Interferon-gamma/metabolismMESH
MaleMESH
Microtubule-Associated Proteins/biosynthesisMESH
Middle AgedMESH
Multiple Myeloma/metabolismMESH
Neoplasm Proteins/biosynthesisMESH
Receptors, CCR7MESH
Receptors, Chemokine/biosynthesisMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14501
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