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Defibrotide: an endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo

Koehl, Gudrun E. ; Geissler, Edward K. ; Iacobelli, Massimo ; Frei, Caroline ; Burger, Verena ; Haffner, Silvia ; Holler, Ernst ; Andreesen, Reinhard ; Schlitt, Hans J. ; Eissner, Günther


Defibrotide (DF) is a polydisperse mixture of 90% single-stranded oligonucleotides with anti-thrombotic and anti-apoptotic functions. DF is used in the treatment of endothelial complications in the course of allogeneic stem cell transplantation. Recent preclinical evidence suggests that DF might also have anti-neoplastic properties. In the present study we hypothesized that DF might inhibit ...


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