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Molecular cloning of two west african human immunodeficiency virus type 2 isolates which replicate well on macrophages: a gambian isolate from a case of neurologic acquired immunodeficiency syndrome, and highly divergent Ghanesian isolate

Kühnel, H. ; von Briesen, H. ; Dietrich, U. ; Adamski, M. ; Mix, D. ; Biesert, L. ; Kreutz, R. ; Immelmann, A. ; Henco, K. ; Meichsner, C. ; Andreesen, Reinhard ; Gelderblom, H. ; Rübsamen-Waigmann, H.


Human immunodeficiency virus type 2 (HIV-2)-related viruses were isolated from a Gambian dying of exclusively neurological disease (HIV-2D194) and from an asymptomatic Ghanian (HIV-2D205). Both strains exhibited properties of HIV-1 biological subtype c: they grew slowly and induced few or no syncytia but eventually produced high levels of particle-associated reverse transcriptase in cultures of ...


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