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Prediction of progression of non-muscle-invasive bladder cancer by WHO 1973 and 2004 grading and by FGFR3 mutation status: a prospective study.

Burger, Maximilian ; van der Aa, Madelon N. M. ; van Oers, Johanna M. M. ; Brinkmann, Anke ; van der Kwast, Theodorus H. ; Steyerberg, Ewout C. ; Stoehr, Robert ; Kirkels, Wim J. ; Denzinger, Stefan ; Wild, Peter J. ; Wieland, Wolf F. ; Hofstaedter, Ferdinand ; Hartmann, Arndt ; Zwarthoff, Ellen C.


OBJECTIVES: The clinical management of non-muscle-invasive urothelial cell carcinoma of the bladder (UCC) is challenging, as it has a marked tendency to recur and to progress. Aim of this study was to investigate the prognostic value of the WHO 1973 and 2004 grading systems and biomarkers FGFR3, CK20 and Ki-67. METHODS: In a prospective study, tumours from 221 patients were studied for the ...


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