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Human monocytes induce a carcinoma cell line to secrete high amounts of nitric oxide

Konur, A. ; Krause, S. W. ; Rehli, M. ; Kreutz, M. ; Andreesen, Reinhard


Nitric oxide (NO) is a short-lived pleiotropic mediator with a multitude of biologic functions. The inducible form of NO synthase (iNOS) is responsible for the discontinuous production of high amounts of NO and is important for the cytotoxic capacity of macrophages in rodents, whereas NO production by human macrophages or monocytes (MO) is under debate. Here we report that high amounts of NO are ...


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