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Spontaneous proliferation of peripheral blood lymphocytes as an indicator of intragraft immune activation in liver transplant patients

Kiuchi, T. ; Kato, H. ; Kanaya, S. ; Nashan, Björn ; Schlitt, Hans-Jürgen ; Inamoto, T. ; Ringe, B. ; Ozawa, K. ; Pichlmayr, R.


The presence of activated lymphocytes in the blood of transplant recipients is considered to be a marker of an ongoing immune process. In this study, the clinical utility of spontaneous proliferation (SP) of peripheral blood mononuclear cells (PBMC) as a marker of in vivo activation was evaluated by in vitro [3H]thymidine incorporation in 22 patients in the 1st month after liver transplantation. ...


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