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Monoclonal antibodies to common epitopes of the human alpha/beta T-cell receptor preferentially activate CD45RA+ T-cells

DOI to cite this document:
Schwinzer, Reinhard ; Schlitt, Hans-Jürgen ; Wonigeit, Kurt
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Date of publication of this fulltext: 10 May 2010 12:17


The murine monoclonal antibody BMA 031 (IgG2b) is directed to a monomorphic epitope on the human alpha/beta T-cell receptor. In contrast to anti-CD3 antibodies of the IgG2b isotype, BMA 031 is able to induce a proliferative response in T-cells from IgG2b low responders. This response occurs independently of cross-linking conditions indicating that the mode of activation differs from stimulation ...


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