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Ciclosporin metabolite pattern in blood and urine of liver graft recipients. II. Influence of cholestasis and rejection

Christians, U. ; Kohlhaw, K. ; Budniak, J. ; Bleck, J. S. ; Schottmann, R. ; Schlitt, Hans-Jürgen ; Almeida, V. M. ; Deters, M. ; Wonigeit, K. ; Pichlmayr, R.
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Date of publication of this fulltext: 10 May 2010 12:17


Abstract

The pattern of metabolites of ciclosporin in blood and 24 h-urine of 58 liver graft recipients was routinely monitored by HPLC from transplantation until discharge from hospital. Liver function and ciclosporin metabolite pattern in patients with an uncomplicated clinical course and in those with cholestasis or acute rejection were compared. During cholestasis M19 and M1A, and during acute ...

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