Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I. Association of ciclosporin metabolites with nephrotoxicity

DOI to cite this document:: 10.5283/epub.14721

Christians, U. ; Kohlhaw, K. ; Budniak, J. ; Bleck, J. S. ; Schottmann, R. ; Schlitt, Hans-Jürgen ; Almeida, V. M. ; Deters, M. ; Wonigeit, K. ; Pichlmayr, R.

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Date of publication of this fulltext: 10 May 2010 12:18

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Abstract

Blood ciclosporin (Cs) metabolite pattern in 58 liver grafted patients was routinely monitored by HPLC from the first Cs dose after transplantation until discharge from hospital. Eighteen patients with normal kidney function were allocated to Group I and 14 patients in Group II suffered Cs nephrotoxicity during their clinical course. There were no significant differences between both groups in ...