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Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function

Bleck, J. S. ; Schlitt, Hans-Jürgen ; Christians, U. ; Schottmann, R. ; Thiesemann, C. ; Strohmeyer, S. ; Kohlhaw, K. ; Wonigeit, K. ; Pichlmayr, R. ; Sewing, K. F.
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Date of publication of this fulltext: 10 May 2010 12:19


Abstract

Ciclosporin, an immunosuppressant, is metabolized by the liver cytochrome P450 system. Changes in the pattern of its metabolites in blood and urine in patients with disturbed liver function have been studied. Forty seven kidney graft patients receiving 2.9 mg/kg/d ciclosporin b.i.d., and no additional medication that would interfere with ciclosporin metabolism, were allocated to three groups ...

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