Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.14726

Schlitt, Hans-Jürgen ; Christians, U. ; Bleck, J. ; Kohlhaw, K. ; Ringe, B. ; Bunzendahl, H. ; Sewing, K. F. ; Wonigeit, K. ; Pichlmayr, R.

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Veröffentlichungsdatum dieses Volltextes: 10 Mai 2010 12:22

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Zusammenfassung

The aim of this study was to analyse the immunosuppressive contribution of cyclosporin metabolites in liver-grafted patients. Therefore the immunosuppressive potency of 17 metabolites, alone and in combination, was tested in human mixed lymphocyte cultures, and the results were correlated with metabolite blood levels in liver-grafted patients. Of the 17 metabolites tested only six highly ...