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Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction

Schlitt, Hans-Jürgen ; Christians, U. ; Bleck, J. ; Kohlhaw, K. ; Ringe, B. ; Bunzendahl, H. ; Sewing, K. F. ; Wonigeit, K. ; Pichlmayr, R.
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Date of publication of this fulltext: 10 May 2010 12:22


Abstract

The aim of this study was to analyse the immunosuppressive contribution of cyclosporin metabolites in liver-grafted patients. Therefore the immunosuppressive potency of 17 metabolites, alone and in combination, was tested in human mixed lymphocyte cultures, and the results were correlated with metabolite blood levels in liver-grafted patients. Of the 17 metabolites tested only six highly ...

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