Different activation states of human lymphocytes after antibody-mediated stimulation via CD3 and the alpha/beta T-cell receptor

DOI to cite this document:: 10.5283/epub.14729

Schlitt, Hans-Jürgen ; Schwinzer, R. ; Wonigeit, K.

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Date of publication of this fulltext: 10 May 2010 12:26

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Abstract

BMA031 is an IgG2b antibody directed towards the human alpha/beta T-cell receptor that is able to induce proliferation of peripheral blood mononuclear cells independent of antibody crosslinking. The proliferative response to BMA031 during the first 3 days of culture is usually of similar magnitude to that induced by the IgG2a CD3 antibody OKT3 but decreases quickly afterwards. Stimulation by ...