T cell activation by monoclonal antibodies directed to different epitopes on the human T cell receptor/CD3 complex: evidence for two different modes of activation

DOI to cite this document:: 10.5283/epub.14732

Schlitt, Hans-Jürgen ; Kurrle, R. ; Wonigeit, K.

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Date of publication of this fulltext: 10 May 2010 12:27

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Abstract

The mouse monoclonal antibody (mAb) BMA031 (IgG2b) has recently been described to be directed against a monomorphic part of the human T cell receptor (TcR) alpha/beta. In vitro analysis of its stimulatory potential for mononuclear cells revealed two patterns of responsiveness. Out of 35 tested individuals only 2 generated a proliferative response to low antibody concentrations (15 ng/ml; "high ...