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Urinary excretion of ciclosporin and 17 of its metabolites in renal allograft recipients

Bleck, J. S. ; Schlitt, Hans-Jürgen ; Christians, U. ; Thiesemann, C. ; Strohmeyer, S. ; Schottmann, R. ; Kohlhaw, K. ; Wonigeit, K. ; Sewing, K. F.



Abstract

Renal elimination of the immunosuppressant ciclosporin is virtually unknown. Therefore, in 17 renal allograft recipients under steady-state conditions we studied the urinary excretion of ciclosporin and 17 of its metabolites in blood and 24-hour urine. Patients with liver dysfunction or treated with drugs potentially influencing the metabolism and elimination of ciclosporin were excluded from the ...

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