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Interactions between bladder tumor cells as tumor spheroids from the cell line J82 and human endothelial cells in vitro

Knüchel, R. ; Feichtinger, J. ; Recktenwald, A. ; Hollweg, H. G. ; Franke, P. ; Jakse, G. ; Rammal, E. ; Hofstädter, Ferdinand



Abstract

Multicellular tumor spheroids (MCTS) are a reliable model of nonvascularized tumor cell aggregates showing a well defined three-dimensional growth pattern and are comparable with small metastatic cancer cell complexes in blood circulation. In the present study we have established a co-culture system of multicellular bladder tumor spheroids with human endothelial cells on extracellular matrix ...

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