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Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid

Kriegmair, M. ; Baumgartner, R. ; Knuechel, R. ; Steinbach, P. ; Ehsan, A. ; Lumper, W. ; Hofstädter, Ferdinand ; Hofstetter, A.



Abstract

OBJECTIVES: Tiny papillary tumors and flat urothelial lesions such as dysplasia or carcinoma in situ can easily be missed during routine cystoscopy. Various methods for in vivo detection of fluorescing agents (preferentially localized in malignant tissue) have been developed. Most of them are based on systemically administered synthetic porphyrin compounds and require sensitive detection devices ...

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