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Differentiation patterns in two- and three-dimensional culture systems of human squamous carcinoma cell lines

Knuechel, R. ; Keng, P. ; Hofstaedter, Ferdinand ; Langmuir, V. ; Sutherland, R. M. ; Penney, D. P.


Relative quantification of the pattern of differentiation of two squamous carcinoma cell lines of the female genital tract, A431 and CaSki, was studied in various experimental tissue culture states that are frequently used to evaluate drug and radiation effects on human tumors. Two- and three-dimensional in vitro cultures, ie, monolayers and multicellular tumor spheroids (MCTS), and nude ...


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