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The effect of retinoic acid on chemosensitivity of PA-1 human teratocarcinoma cells and its modulation by an activated N-ras oncogene

Le-Ruppert, K. ; Masters, J. R. ; Knuechel, R. ; Seegers, S. ; Tainsky, M. A. ; Hofstaedter, Ferdinand ; Buettner, R.


Combination of chemotherapeutic drugs with agents that induce cell differentiation is a possible means of improving cancer chemotherapy. To explore this approach we used 4 cell lines established from the human teratocarcinoma-derived cell line PA-1; 2 retinoic acid (RA)-sensitive lines compared to 2 RA-resistant lines transformed by an activated N-ras oncogene. Equal numbers of colony-forming ...


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