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In vitro investigations on cellular damage induced by high energy shock waves

Steinbach, P. ; Hofstädter, Ferdinand ; Nicolai, H. ; Rössler, W. ; Wieland, W.



Abstract

Single-cell suspensions of the prostate carcinoma cell line PCA were exposed to electromagnetically generated ultrasound shock waves (source and focusing lens identical to those used in the commercially available lithotripor Lithostar Plus). Cell loss of up to 40% occurred in sample tubes containing air. To expose multicellular tumor spheroids and cells growing on a microcarrier, an experimental ...

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