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Proliferation of tumor spheroids after shock-wave treatment

Nicolai, H. ; Steinbach, P. ; Knuechel-Clarke, R. ; Grimm, D. ; Roessler, W. ; Wieland, W. F. ; Hofstaedter, Ferdinand


Multicellular tumor spheroids (MCTS) grown from the bladder cancer cell line RT112 and from the prostate cancer cell line PCA were exposed to 200 or 800 electromagnetically generated focused ultrasound shock waves. RT112 cells showed a distinct but transient decrease in proliferation whereas the effect of PCA cells was less pronounced. Flow-cytometric measurements of DNA content and Ki67 ...


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