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Human follicular and papillary thyroid carcinoma cells interact differently with human venous endothelial cells

Grimm, D. ; Bauer, J. ; Kromer, E. ; Steinbach, P. ; Riegger, G. ; Hofstädter, Ferdinand



Abstract

Follicular thyroid carcinomas (FTC) characteristically spread via blood vessels, while papillary thyroid carcinomas (PTC) predominantly metastasize to lymph nodes. This different behavior of cancer cells originating from one organ was investigated by layering multicellular tumor spheroids (MCTS) consisting of various kinds of human thyroid cells onto confluent monolayers of human venous ...

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