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Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics

Rüschoff, J. ; Dietmaier, W. ; Lüttges, J. ; Seitz, G. ; Bocker, T. ; Zirngibl, H. ; Schlegel, J. ; Schackert, H. K. ; Jauch, K. W. ; Hofstaedter, Ferdinand



Abstract

Clinicopathological evidence has accumulated that colorectal adenocarcinoma with minimal or no glandular differentiation constitutes two entities with different prognosis. In a series of 20 predominantly nonglandular, poorly differentiated adenocarcinomas, histological features, DNA content, p53 protein expression, Ki-ras mutation, and microsatellite instability were analyzed and correlated to ...

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