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Photosensitization of human skin cell lines by ATMPn [9-acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene] in vitro: mechanism of action

Fickweiler, S. ; Abels, C. ; Karrer, S. ; Bäumler, W. ; Landthaler, M. ; Hofstädter, Ferdinand ; Szeimies, R. M.


9-Acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene (ATMPn) is a promising new photosensitizer characterized by high absorption around 640 nm and high singlet oxygen yield. To study the mechanism of action in vitro we have investigated uptake, intracellular localization, cell survival and ultrastructural changes following photodynamic treatment in human cell lines derived from the skin ...


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