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Clonality and genetic divergence in multifocal low-grade superficial urothelial carcinoma as determined by chromosome 9 and p53 deletion analysis

Hartmann, A. ; Rösner, U. ; Schlake, G. ; Dietmaier, W. ; Zaak, D. ; Hofstaedter, Ferdinand ; Knuechel, R.


Multifocality and recurrence are clinically important features of urothelial carcinomas of the urinary bladder. Recent molecular genetic studies have suggested that multifocal urothelial carcinomas are monoclonally derived from an identical transformed progenitor cell. However, most of these studies investigated advanced and poorly differentiated tumors. The study presented focuses on early ...


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