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Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma

Heinmöller, E. ; Dietmaier, W. ; Zirngibl, H. ; Heinmöller, P. ; Scaringe, W. ; Jauch, K. W. ; Hofstädter, Ferdinand ; Rüschoff, J.


Little or no data exist concerning the inactivation of tumor suppressor genes in intraductal lesions surrounding invasive ductal pancreatic carcinomas. Using a novel improved primer extension and preamplification polymerase chain reaction, we analyzed microdissected paraffin-embedded specimens of pancreatic carcinoma (n = 29) and their corresponding pancreatic intraductal lesions (PIL, n = 331) ...


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