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Indocyanine green (ICG) and laser irradiation induce photooxidation

Abels, C. ; Fickweiler, S. ; Weiderer, P. ; Bäumler, W. ; Hofstädter, Ferdinand ; Landthaler, M. ; Szeimies, R. M.


The cellular uptake and subcellular localization of indocyanine green (ICG; absorption band 700-850 nm), and cell survival and ultrastructural changes following ICG-mediated phototherapy were investigated in vitro in four different cell lines derived from human skin (SCL1 and SCL2 squamous cell carcinoma, HaCaT keratinocytes and N1 fibroblasts). The cellular uptake of ICG (1-50 microM, incubation ...


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