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Microsatellite instability in tumor and nonneoplastic colorectal cells from hereditary non-polyposis colorectal cancer and sporadic high microsatellite-instable tumor patients

Dietmaier, W. ; Gänsbauer, S. ; Beyser, K. ; Renke, B. ; Hartmann, A. ; Rümmele, P. ; Jauch, K. W. ; Hofstädter, Ferdinand ; Rüschoff, J.



Abstract

Genetic alterations such as loss of heterozygosity (LOH) and microsatellite instability (MSI) have been frequently studied in various tumor types. Genetic heterogeneity of nonneoplastic cells has not yet been sufficiently investigated. However, genomic instability in normal cells could be a potentially important issue, in particular when these cells are used as reference in LOH and MSI analyses ...

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