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Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent

Jeschke, M. G. ; Richter, G. ; Herndon, D. N. ; Geissler, E. K. ; Hartl, M. ; Hofstädter, Ferdinand ; Jauch, K. W. ; Perez-Polo, J.-R.


It is well documented that responses to growth factor treatment typically display bell-shaped dose responses that can significantly affect efficacy. Here we tested the hypothesis that nonviral liposomal gene delivery also displays this characteristic. We chose two different growth factors, keratinocyte growth factor (KGF) and insulin-like growth factor-I (IGF-I) CMV-driven transfecting constructs ...


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