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Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder

Hartmann, Arndt ; Schlake, Gudrun ; Zaak, Dirk ; Hungerhuber, Edwin ; Hofstetter, Alfons ; Hofstaedter, Ferdinand ; Knuechel, Ruth


To define the genetic changes of flat urothelial lesions, carcinoma in situ (CIS) and moderate dysplasias (DII) were investigated for alterations in the two chromosomal regions most frequently involved in bladder cancer. Overall, 33 CIS and 16 DII from 21 patients were used to microdissect urothelium. Dual color fluorescence in situ hybridization (FISH) using gene locus probes of 9q22 (FACC), ...


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