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Glucose transporter 1 gene expression is related to thyroid neoplasms with an unfavorable prognosis: an immunohistochemical study

Schönberger, Johann ; Rüschoff, J. ; Grimm, Daniela ; Marienhagen, Jörg ; Rümmele, Petra ; Meyringer, Rotraud ; Kossmehl, Peter ; Hofstaedter, Ferdinand ; Eilles, Christoph



Abstract

PURPOSE: An accelerated rate of glucose metabolism mediated by overexpression of key regulatory glycolytic enzymes and glucose transporters is among the most characteristic biochemical marker of malignant transformed cells. In thyroid neoplasms, however, an increased uptake of glucose [measured by 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET)] seems to be ...

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