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Frequent microsatellite instability in sporadic tumors of the upper urinary tract

Hartmann, Arndt ; Zanardo, Livia ; Bocker-Edmonston, Tina ; Blaszyk, Hagen ; Dietmaier, Wolfgang ; Stoehr, Robert ; Cheville, John C. ; Junker, Kerstin ; Wieland, Wolf ; Knuechel, Ruth ; Rueschoff, Josef ; Hofstaedter, Ferdinand ; Fishel, Richard



Abstract

Urothelial carcinoma of the renal pelvis and ureter may develop sporadically or as a manifestation of hereditary nonpolyposis colorectal cancer. The majority of hereditary nonpolyposis colorectal cancer is caused by mutation of the human DNA mismatch repair (MMR) genes and is detected by associated microsatellite instability (MSI). Seventy-three unselected urothelial carcinomas of the ureter ...

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