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Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses

Obermann, E. C., Junker, K., Stoehr, R., Dietmaier, W., Zaak, D., Schubert, J., Hofstaedter, Ferdinand, Knuechel, Ruth and Hartmann, A. (2003) Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses. The Journal of pathology 199 (1), pp. 50-57.

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Abstract

Flat urothelial hyperplasia, defined as markedly thickened urothelium without cytological atypia, is regarded in the new WHO classification as a urothelial lesion without malignant potential. Frequent deletions of chromosome 9 detected by fluorescence in situ hybridization (FISH) have been previously reported in flat urothelial hyperplasias found in patients with papillary bladder cancer. Using ...

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Item type:Article
Date:2003
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
12474226PubMed ID
10.1002/path.1259DOI
Classification:
NotationType
AgedMESH
Carcinoma, Papillary/pathologyMESH
Chromosome DeletionMESH
Chromosomes, Human, Pair 9/geneticsMESH
FemaleMESH
Genome, HumanMESH
HumansMESH
Hyperplasia/geneticsMESH
In Situ Hybridization, Fluorescence/methodsMESH
Loss of Heterozygosity/geneticsMESH
MaleMESH
Middle AgedMESH
Neoplasm InvasivenessMESH
Nucleic Acid HybridizationMESH
Urinary Bladder Neoplasms/pathologyMESH
Urothelium/pathologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:15407
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