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Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses

Obermann, E. C. ; Junker, K. ; Stoehr, R. ; Dietmaier, W. ; Zaak, D. ; Schubert, J. ; Hofstaedter, Ferdinand ; Knuechel, Ruth ; Hartmann, A.



Abstract

Flat urothelial hyperplasia, defined as markedly thickened urothelium without cytological atypia, is regarded in the new WHO classification as a urothelial lesion without malignant potential. Frequent deletions of chromosome 9 detected by fluorescence in situ hybridization (FISH) have been previously reported in flat urothelial hyperplasias found in patients with papillary bladder cancer. Using ...

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