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Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers

Woenckhaus, M. ; Klein-Hitpass, L. ; Grepmeier, U. ; Merk, J. ; Pfeifer, M. ; Wild, P. J. ; Bettstetter, M, ; Wuensch, P, ; Blaszyk, Hagen ; Hartmann, Arndt ; Hofstaedter, Ferdinand ; Dietmaier, Wolfgang



Abstract

Tobacco smoking is the leading cause of lung cancer worldwide. Gene expression in surgically resected and microdissected samples of non-small-cell lung cancers (18 squamous cell carcinomas and nine adenocarcinomas), matched normal bronchial epithelium, and peripheral lung tissue from both smokers (n = 22) and non-smokers (n = 5) was studied using the Affymetrix U133A array. A subset of 15 ...

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