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Histologic-genetic mapping by allele-specific PCR reveals intraurothelial spread of p53 mutant tumor clones

Stoehr, Robert ; Knuechel, Ruth ; Boecker, Joerg ; Blaszyk, Hagen ; Schmitt, Ruediger ; Filbeck, Thomas ; Hofstaedter, Ferdinand ; Hartmann, Arndt



Abstract

Common and clinically important features of urothelial carcinomas are multifocality and a high rate of recurrence. Molecular studies demonstrated that multifocal tumors are frequently composed of one tumor clone spreading throughout the urothelial tract. A combination of histologic and genetic mapping of cystectomy specimens from bladder cancer patients is a valuable tool to study bladder ...

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