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Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern

Hafner, Christian ; López-Knowles, Elena ; Luis, Nuno M. ; Toll, Agustí ; Baselga, Eulàlia ; Fernández-Casado, Alex ; Hernández, Silvia ; Ribé, Adriana ; Mentzel, Thomas ; Stoehr, Robert ; Hofstaedter, Ferdinand ; Landthaler, Michael ; Vogt, Thomas ; Pujol, Ramòn M. ; Hartmann, Arndt ; Real, Francisco X.



Abstract

Activating mutations of the p110 alpha subunit of PI3K (PIK3CA) oncogene have been identified in a broad spectrum of malignant tumors. However, their role in benign or preneoplastic conditions is unknown. Activating FGF receptor 3 (FGFR3) mutations are common in benign skin lesions, either as embryonic mutations in epidermal nevi (EN) or as somatic mutations in seborrheic keratoses (SK). FGFR3 ...

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