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No evidence for involvement of beta-catenin and APC in urothelial carcinomas

Stoehr, Robert ; Krieg, Rene C. ; Knuechel, Ruth ; Hofstaedter, Ferdinand ; Pilarsky, Christian ; Zaak, Dirk ; Schmitt, Ruediger ; Hartmann, Arndt



Abstract

The wnt pathway plays an important role in embryonal patterning and cell fate determination, involving stabilization of nuclear and cytoplasmic beta-catenin (CTNNB1) mediated by APC, axin, and other proteins. Uncomplexed beta-catenin binds to TCF/LEF transcription factors and activates the expression of growth regulatory target genes such as c-myc or cyclin D1. In colorectal and other cancers, ...

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