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Hereditary nonpolyposis colorectal cancer syndrome in a patient with urothelial carcinoma of the upper urothelial tract

Hartmann, Arndt ; Cheville, John C. ; Dietmaier, Wolfgang ; Hofstädter, Ferdinand ; Burgart, Lawrence J. ; Blaszyk, Hagen



Abstract

Urothelial carcinoma of the upper urinary tract is relatively uncommon but may develop as a manifestation of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC), which is characterized by mutations in a number of DNA mismatch repair genes and detectable as microsatellite instability or loss of the respective protein by immunostaining. No well-established screening test is available for ...

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