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Urothelial carcinoma of the upper urinary tract: inverted growth pattern is predictive of microsatellite instability

Hartmann, Arndt ; Dietmaier, Wolfgang ; Hofstädter, Ferdinand ; Burgart, Lawrence J ; Cheville, John C. ; Blaszyk, Hagen



Abstract

Urothelial carcinoma of the renal pelvis and ureter may develop as a manifestation of hereditary nonpolyposis colorectal cancer syndrome (HNPCC), a disorder characterized by mutation or inactivation of a number of DNA mismatch repair genes and detectable as microsatellite instability (MSI). Some urothelial carcinomas display areas of endophytic, or inverted, growth. In this study, urothelial ...

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