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Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation

Woenckhaus, Matthias ; Stoehr, Robert ; Dietmaier, Wolfgang ; Wild, Peter J. ; Zieglmeier, Ulrike ; Foerster, Julia ; Merk, Johannes ; Blaszyk, Hagen ; Pfeifer, Michael ; Hofstaedter, Ferdinand ; Hartmann, Arndt


Genetic alterations at chromosome arm 8p are associated with advanced disease and poor patient outcome in several types of malignant tumors. We studied the frequency of microsatellite instability (MSI) and loss of heterozygosity (LOH) at chromosome 8p in early stage non-small cell lung cancer (NSCLC) of 47 patients with stage I or II disease (25 squamous cell carcinomas and 22 adenocarcinomas). ...


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