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Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers

Grepmeier, Ulrike ; Dietmaier, Wolfgang ; Merk, Johannes ; Wild, Peter J. ; Obermann, Ellen C. ; Pfeifer, Michael ; Hofstaedter, Ferdinand ; Hartmann, Arndt ; Woenckhaus, Matthias


Most lung cancer is attributed to long-term smoking. In order to define chromosomal regions with an accumulation of smoking-related early molecular damage, we applied 15 microsatellite markers at 8 chromosomal regions (2q35-q36, 3p21.3, 3p14.2, 3p25, 10q11.2, 11p14-15, 12p13.1-p12.3 and 12q14) in an allelotyping study. We studied samples of 42 patients with primary non-small cell lung cancer ...


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