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No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract

Stoehr, Robert ; Brinkmann, Anke ; Filbeck, Thomas ; Gamper, Christoph ; Wild, Peter ; Blaszyk, Hagen ; Hofstaedter, Ferdinand ; Knuechel, Ruth ; Hartmann, Arndt


Mutational activation of the MAP kinase pathway is frequently found in various cancers. Recently, activating mutations in the B-RAF gene, an important activator of this pathway, have been described in several tumor types including melanoma, colorectal and papillary thyroid cancer. The most frequent mutation in exon 15 (V599E), as well as several other mutations within exons 11 and 15 result in ...


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