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FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization

Hafner, Christian ; Hartmann, Arndt ; van Oers, Johanna M. M. ; Stoehr, Robert ; Zwarthoff, Ellen C. ; Hofstaedter, Ferdinand ; Landthaler, Michael ; Vogt, Thomas



Abstract

Somatic activating fibroblast growth factor 3 (FGFR3) mutations in human skin can cause seborrheic keratoses, one of the most frequent skin tumors in man. However, details of the involved mechanisms remain elusive. We analyzed 65 acanthotic seborrheic keratoses with varying vertical diameters for FGFR3 mutations using a SNaPshot multiplex assay. Immunohistochemistry was performed for Ki-67, bcl-2 ...

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