A Generalized Eigendecomposition Approach Using Matrix Pencils to Remove Artifacts from 2D NMR Spectra

Abstract

Multidimensional 1 H nmr spectra of biomolecules dissolved in light water are contaminated by an intense water artefact. We dis- cuss the application of the generalized eigenvalue decomposition (GEVD) method using a matrix pencil to explore the time structure of the signals in order to separate out the water artefacts. Simulated as well as experi- mental 2D NOESY spectra of proteins are studied. Results are compared to those obtained with the FastICA algorithm.