Cardiovascular effects of modulators of soluble guanylyl cyclase activity.

URN to cite this document:: urn:nbn:de:bvb:355-epub-156576
DOI to cite this document:: 10.5283/epub.15657

Hoenicka, Markus ; Schmid, Christof

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Date of publication of this fulltext: 05 Jul 2010 15:31

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Abstract

Soluble guanylyl cyclase (sGC) is one of the key enzymes of the nitric-oxide (NO)/cyclic 3',5'-guanosine monophosphate (cGMP) pathway. Located in virtually all mammalian cells, it controls the vessel tone, smooth muscle cell growth, platelet aggregation, and leukocyte adhesion. In vivo sGC activity is mainly regulated by NO which in turn is released from L-arginine by nitric oxide synthases. One ...