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Melanoma inhibitory activity (MIA) protein - molecular relevance and functional characterization

URN to cite this document:
urn:nbn:de:bvb:355-epub-156839
DOI to cite this document:
10.5283/epub.15683
Schmidt, Jennifer
Date of publication of this fulltext: 04 May 2011 08:54


Abstract (English)

Melanoma inhibitory activity (MIA), an 11 kDa protein expressed and secreted by malignant melanoma cells, plays a key role in development and progression of malignant melanoma. It facilitates the release of tumor cells from the primary tumor and thus strongly promotes formation of metastases. However, the processing of MIA protein during cell migration and the characterization of protein activity ...

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Translation of the abstract (German)

Melanoma inhibitory activity (MIA), ein 11 kDa großes Protein, wird von malignen Melanomzellen exprimiert und sekretiert. MIA Protein spielt eine wichtige Rolle bei der Entwicklung und Progression des malignen Melanoms. Durch direkte Interaktion mit Zelladhäsionsmolekülen und Strukturen der extrazellulären Matrix erleichtert MIA Protein das Ablösen von entarteten Zellen aus dem Primärtumorverband ...

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