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Melanoma inhibitory activity (MIA) protein - molecular relevance and functional characterization

Schmidt, Jennifer (2011) Melanoma inhibitory activity (MIA) protein - molecular relevance and functional characterization. PhD, Universität Regensburg.

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Date of publication of this fulltext: 04 May 2011 08:54

Abstract (English)

Melanoma inhibitory activity (MIA), an 11 kDa protein expressed and secreted by malignant melanoma cells, plays a key role in development and progression of malignant melanoma. It facilitates the release of tumor cells from the primary tumor and thus strongly promotes formation of metastases. However, the processing of MIA protein during cell migration and the characterization of protein activity ...

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Translation of the abstract (German)

Melanoma inhibitory activity (MIA), ein 11 kDa großes Protein, wird von malignen Melanomzellen exprimiert und sekretiert. MIA Protein spielt eine wichtige Rolle bei der Entwicklung und Progression des malignen Melanoms. Durch direkte Interaktion mit Zelladhäsionsmolekülen und Strukturen der extrazellulären Matrix erleichtert MIA Protein das Ablösen von entarteten Zellen aus dem Primärtumorverband ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:4 May 2011
Referee:Prof. Dr. Burkhard König and Prof. Dr. Anja Katrin Bosserhoff
Date of exam:26 April 2010
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:malignant melanoma, MIA, cell migration, protein secretion, formation of metastases, protein dimerization, inhibition of protein dimerization
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:15683
Owner only: item control page

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